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CURRICULUM VITAE OF MICHAEL J EVANS

MICHAEL J. EVANS, Ph.D. 
Center for Comparative Respiratory Biology and Medicine
University of California at Davis
Davis, California 95616 - (530)7547540
Home Address; 2434 Bucklebury Road
Davis California 95616 - (530)75 84270

EDUCATION 

1968  Ph.D.,  Biology. Specialty training in Cellular Biology, University of Southern California,  Los Angeles,CA.

1962  A.B, Biology and Chemistry,  Whittier College, Whittier, CA. 

PROFESSIONAL AND TEACHING EXPERIENCE 

1999 to Present, Research Faculty, Department of Anatomy, Physiology and Cell Biology, UCD School of Veterinary Medicine, Davis, California (part time). 

1997-1999, Visiting Professor, Department of Anatomy, Physiology and Cell Biology, UCD School of Veterinary Medicine, Davis, California (part time). 

1993-1997, Artist in Residence, Truckee, California. 

1987-1993, Professor of Internal Medicine and Anatomy & Neurosciences, The University of Texas Medical Branch, Galveston Texas, and Director of the Electron Microscopy Laboratory, Shrine Burns Institute, Galveston, Texas.

   Courses  taught: Pulmonary Pathophysiology Series and Microanatomy for first-term medical students, Anatomy and Neurosciences Graduate Program. (Retired in 1993). 

1985-1987, Professor of Medicine, Pulmonary Division, Department of Medicine, UCLA School of Medicine, Los Angeles, California.

   Courses taught: Lung Cell Biology Seminar Series, Environmental Toxicology, Pathologic Toxicology, School of Public Health Graduate Program. 

1983-1985, Senior Staff Scientist, Director of Electron Microscopy Laboratory, Lovelace Inhalation Toxicology Research Institute, Albuquerque, New Mexico. 

1981-1983, Artist in Residence and Instructor at Yuba College, Clear Lake, California.

   Courses taught: Biology and Genetics; Lifetime California Community College Teaching Credential in Biology. 

1969-1981, Cell Biologist, Program Manager of Cell Growth Program; Associate Director of the Medical Sciences Department, Stanford Research Institute (SRI International), Menlo Park, California. (Retired in 1981). 

1969-1981, Consultant, Environmental Medicine Department, Rancho Los Amigos Hospital, Downey, California. 

1968-1969, Research Associate, Pathology, USC School of Medicine.   Courses taught: Electron Microscopy, General Biology and Cell Physiology. 

1965-1967, Research Assistant, Electron Microscopy Laboratory, University of Southern California 

1963-1965, Teaching Assistant, Department of Biological Sciences, University of Southern California, Los Angeles, CA.

   Courses taught: General Biology, Botany, Anatomy, Physiology, Cell Physiology, Electron Microscopy. 

1962-1963, Analytical Chemist, Cardiovascular Laboratory, Rancho Los Amigos Hospital, Downey, California. 

RESEARCH HISTORY 

AREAS OF RESEARCH 

1987-present; Cell adhesion; pulmonary injury and repair; cell kinetics; functions of airway basal cells and the lateral intercellular space, basement membrane biology, remodeling in asthma. 

1985-1987; Basic cell kinetics research concerning alveolar macrophage and mucous cell proliferation.  Anatomical investigations concerning the role of the basal cell in the lung.  Continued research in oxygen toxicity, (UCLA School of Medicine) 

1983-1985; Research on basic mechanisms of injury and repair in the lung, including the role of  inflammatory cells and those of the immune system on alveolar cell proliferation.  (Lovelace Inhalation Toxicology Research Institute) 

1969-1981; Research on basic mechanism of cell renewal in the lung and the effects of oxidants on this process; studies on oxidant-induced injury and repair in aging animals; studies on bacteria-macrophage interaction in mice infected with M. Leprae; pathology of chemotherapeutic agents.  (SRI International)   

1963-1965; Dissertation on cell renewal mechanisms of the lung; studies of aging rats exposed to  ozone. (University of Southern California) 

1962-1963; Chemist associated with clinical studies of the pathogenesis of congestive heart failure;  Microscopic studies of cultured lung cells; studies of oxygen toxicity and pulmonary cell turnover.  (Rancho Los Amigos Amigos Hospital) 

GRANT & EDITORIAL REVIEW 

International Grant Review

   Basic Research Foundation, Israel Academy of Sciences and Humanities
Canadian Institutes of Health Research
Medical Research Council, United Kingdom 

National Grant Review

   National Heart, Lung, and Blood Institute
National Institute of Environmental Health Sciences
National Cancer Institute
Environmental Protection Agency
Department of Energy 

Editorial Review

American Journal of Pathology

American Journal of Physiology: Lung Cellular and Molecular Physiology

American Review of Respiratory Diseases

American Journal of Respiratory, Cellular and Molecular Biology

Anatomical Record

Developmental Dynamics

Environmental Research

Experimental Lung Research (Editorial Board)

Experimental and Molecular Pathology

Journal of Histochemistry and Cytochemistry

Journal of Toxicology and Environmental Health

Journal of Ultrastructrure Research

Laboratory Investigation

Lung

Scanning Electron Microscopy

Science

Toxicology and Applied Pharmacology 

MEMBERSHIP IN SCIENTIFIC SOCIETIES

American Society for Cell Biology

American Association for the Advancement of Science

New York Academy of Science

American Federation of Clinical Research

American Thoracic Society 

GRANT SUPPORT

Principal Investigator  

1990-1993, Shrine Hospital for Crippled Children (SHCC) Grant #15853 - Cell Adhesion in Airways,  $196,210. 

1989-1993, Shrine Hospital for Crippled Children (SHCC) Grant #15813 - Electron Microscope Core Facility, $726,031. 

1988, American Petroleum Institute (API) Contract, Analysis of Data Concerning          the EPA Ozone  Standard, $44,903 

1983-1985, Department of Energy Contract DE-AC04-76EV01013 - Respiratory Tract

Pathophysiology for Inhaled Energy Effluents, $1,600,000. 

1977-1980, National Cancer Institute Grant, RO1 CA19354 - Injury and Tumor Formation in the Rat Lung, $437,000. 

1973-1982, National Institute of Environmental Health Sciences Grant, PO1 ES00842 - Cell Proliferation in the Lung, $767,000. 

1972-1982, National Heart Lung and Blood Institute Grant, RO1 HL16330 - Aging: Tissue Injury and Repair, $260,000. 

1971-1976, National Institute for Allergy and Infectious Disease Grant, RO1 AI10110 - Ultrastructure of M. Lepra Infection, $133,000. 

1970-1973, National Heart Lung and Blood Institute Grant, RO1 HL13373 - Cell Proliferation in the Lung, $120,000. 

1968-1970, California Tuberculosis and Health Association, Oxygen Toxicity in the Lung, $20,00

Co- Investigator  

2002-2005. National Insitute for Environmental Health Sciences PO1 ES11617. Mechanisms of Species Dependent Enviironmental Lung Injury. 4,849,652. (E. Postlethwait P.I.). 

2000-2005. National Insitute for Environmental Health Sciences PO1 ES00628. Pulmonary Effects of Environmental Oxidant Pollutants. $ 4,994,192. (C Plopper P.I.)

 

1998-2000. UC Davis Health System Reward Program. Fibrosis and the Pathogensis of Irreversiable Asthma. $198,530. (J Last P.I.)

 

1990-1992 Shrine Hospital for Crippled Children (SHCC) Grant #15852 - Surgical Studies on Gut Translocation of Bacteria in a Chronic  Ovine Model, $851,571 (D. Traber P.I.).

 

1990-1992 Shrine Hospital for Crippled Children (SHCC) Grant #15857 - Bronchial Lesions of Inhalation Injury, $598,672. (R Barrow P.I.)

 

1987-1992:  National Heart Lung and Blood Institute RO1 HL40675 - Hyperoxia and Lung Macrophages, $135,824, (M. Sherman, Principal Investigator).

 

1987-1989: National Heart Lung and Blood Institute RO1 HL27309 - Lung Injury: Response with Repair and Proliferation, $770,000, (D. Tierney, P.I.).

 

1986-1989:  Environmental Protection Agency EPA-R-812869 - Synergism in Pulmonary Effects of NO2 and O3, $474,000, (M. Mustafa, P.I.).

 

1986-1989: National Heart Lung and Blood Institute RO1 HL36123 - Pulmonary Hypertension: Polyamine and Cell Proliferation, $474,000, (A. Hacker, P.I.).

 

1980-1983: National Heart Lung and Blood Institute RO1 HL28344 - Cell Surface Polysaccharides of Rat Lung, $310,000, (A. Brandt, P.I.).

 

1979-1984: National Cancer Institute RO1 CA25711 - Anthracycline Development, $631,000, (A. Acton, P.I.)

 

1974-1982: Environmental Protection Agency EPA Contract 68-02-1944 - Effects of Oxidants on Lung Lesions, $575,000, (J.Hackney,  P.I.).

 

1970-1982: Office of Naval Research ONR Contract N00014-70-C-0306 - Effects of Oxygen on Cell Division, $240,000, (J.Hackney, P.I.).

 

HONORS

Fellowship from Biological Stain Commission

Phi Sigma

Sigma XI

 


 

ARTICLES IN PEER-REVIEWED JOURNALS:

 

1. Iseri, L.T., J.R. Evans and M.J. Evans.  Pathogenesis of congestive heart failure:  Correlation between anaerobic metabolism and plasma volume changes following exercise.  Ann Intern Med 59:788-797, 1963.

 

2. Iseri. L.T., M.Kaplin, M.J. Evans and E. Nickel.  Effect of concentrated contrast media during  angiography on plasma volume and plasma osmolality.  Am Heart J 69:154-158, 1965.

 

3. Iseri, L.T., R.Smith, and M.J. Evans.  Cardiovascular problems in rehabilitation of hemiplegic  patients.  J Chronic Dis 21:423-434, 1968.

 

4. Hackney, J.D., R.F. Bils, M.J. Evans and D.E. Rounds.  Functional morphological response  of in vitro lung and myocardial test objects of experimental gas environments.  APCA J 18:9- 11, 1968.

 

5. Evans, M.J.  Cellular proliferation in the pulmonary alveoli of the mouse and rat.  Dissertation,  University of Southern California, 1968.

 

6. Evans, M.J. and R.F. Bils.  Identification of tritiated thymidine labeled cells in the pulmonary  alveolar walls of the mouse.  Am Rev Respir Dis 100:372-378, 1969.

 

7. Evans, M.J., J.D. Hackney, and R.F. Bils.  Effects of a high concentration of oxygen on cell renewal in the pulmonary alveoli.  Aerospace Med 40:1365-1369, 1969.

 

8. Evans, M.J. W. Mayr, R.F. Bils and C.G. Loosli.  Effects of ozone on cell renewal in the pulmonary  alveoli of aging mice.  Arch Intern Med 127:873-883, 1971.

 

9. Stephens, R.J., G. Freeman and M.J. Evans.  Ultrastructural changes in connective tissue in lungs  of rats exposed to NO2.  Arch Intern Med 127:873-883, 1971.

 

10. Evans, M.J., R.J. Stephens and G. Freeman.  Effects of NO2 on cell renewal in the rat lung.  Arch Intern Med 128:58-60, 1971.

 

11. Evans, M.J., R.J. Stephens, L. Cabral and G. Freeman.  Cell renewal in the lungs of rats exposed  to low levels of NO2.  Arch Environ Health 24:180-188, 1972.

 

12. Stephens, R.J., G. Freeman and M.J. Evans.  Early responses of lungs to low levels of nitrogen  dioxide.  Arch Environ Health 24:160-179, 1972.

 

13. Evans, M.J. and L. Levy.  Ultrastructural changes in the cells of the mouse footpad infected with M.  Leprae.  Infect and Immunity 43:620-622, 1972.

 

14. Evans, M.J. and J.D. Hackney.  Cell proliferation in lungs of mice exposed to elevated concentrations of oxygen.  Aerospace Med 43:620-622, 1972.

 

15. Freeman, G., S.C. Crane, N.J. Furiosi, R.J. Stephens, M.J. Evans and W.D. Moore.  Covert  reduction of ventilatory surface in rats during prolonged exposure to subacute nitrogen dioxide.  Am Rev Respir Dis 106:563-579, 1972.

 

16. Evans, M.J., L.J. Cabral, R.J. Stephens and G. Freeman.  Renewal of alveolar epithelium in the rat  following exposure to NO2.  Am J Pathol 70:175-198, 1973.

 

17. Evans, M.J., L.J. Cabral, R.J. Stephens and G. Freeman.  Cell division of alveolar macrophages in the rat following exposure to NO 2.  Am J Pathol 70:199-208, 1973.

 

18. Evans, M.J.  J. Netoni and L. Levy.  Early response of the mouse footpad to M. leprae  Infect  and Immunity 7:76-85, 1973.

 

19. Stephens, R.J. and M.J. Evans.  Selection and orientation of lung tissue for electron microscopy.   Environ Res 6:52-59, 1973.

 

20. Evans, M.J. and L.Levy.  Cellular response of the mouse footpad to M. Leprae .  Infect and  Immunity 7:76-85, 1973.

 

21. Levy, L., N. Moon, L.P. Murray, S.M. O’Neill, L.E. Gustafson and M.J. Evans.  Studies of the mouse  footpad technique for cultivation on M. leprae.  I.  Fate of inoculated organisms.  Internat J Leprosy  42:165-173, 1974.

 

22. Stephens, R.J., M.J. Evans, and G. Freeman.  A comprehensive ultrastructural study of pulmonary  injury and repair in the rat resulting from exposure to less than one ppm ozone.  Chest 65:11-13, 1974.

 

23. Evans, M.J., L.J. Cabral, R.J. Stephens and G. Freeman.  Acute kinetic response and renewal of  the alveolar epithelium following injury by nitrogen dioxide.  Chest 65:62-65, 1974.

 

24. Stephens, R.J., M.F. Sloan, M.J. Evans and G. Freeman.  Early response of the lung to low levels  of ozone.  Am J Pathol 74:31-58, 1974.

 

25. Stephens, R.J., M.F. Sloan, M.J. Evans and G. Freeman.  Alveolar Type I cell response to  exposure to 0.5 ppm O3 for short periods.  Exp Mol Pathol 20:22-23, 1974.

 

26. Freeman, G., L.T. Juhos, N.J. Furiosi, R. Mussenden, R.J. Stephens and M.J. Evans.  Pathology  of  pulmonary disease from exposure to interdependent ambient gases (nitrogen dioxide and ozone).  Arch Environ Health 29:203-210, 1974.

 

27. Evans, M.J., L.J. Cabral, R.J. Stephens and G. Freeman.  Transformation of alveolar Type II cells  to Type 1 cells following exposure to NO2.  Exp Mol Pathol 22:142-150, 1975.

 

28. Hackney, J.D., M.J. Evans and C.E. Spier. Effects of 100% oxygen on cell division in lung alveoli of squirrel monkeys.  Aviation Space and Environ Med 1:1340-1342, 1975.

 

29. Levy, L., H. Ngu, M.J. Evans and J.L. Krahenbuhl.  The susceptibility of thymectomized and  irradiated mice to challenge with several bacteria and the effect of dapsone on infection with M.  Leprae.  Infect and Immunity 11:1122-1132, 1975.

 

30. Evans, M.J., L.V. Johnson, R.J. Stephens and G. Freeman. Cell renewal in the lungs of rats  exposed to low levels of ozone.  Exp Mol Pathol 24:70-83, 1976.

 

31. Evans, M.J., L.V. Johnson, R.J. Stephens and G. Freeman.  Renewal of the terminal bronchiolar  epithelium following exposure to O3 and NO2.  Lab Invest  35:246-257, 1976.

 

32. Hackney, J.D., M.J. Evans and B.R. Christie.  Effects of 60 and 80% oxygen on cell division in lung  alveoli of squirrel monkeys.  Aviation Space and Environ Med 1:791-794, 1976.

 

33. Cabral-Anderson, L.J., M.J. Evans and G. Freeman.  Effects of NO2 on the lungs of aging rats.  I.   Morphology.  Exp Mol Pathol 27:366-276, 1977.

 

34. Evans, M.J., L.J. Cabral-Anderson and G. Freeman.  Effects of NO2 on the lung of aging rats.  II.   Cell proliferation.  Exp Mol Pathol 27:366-376, 1977.

 

35. Hackney, J.D., M.J. Evans, R.F. Bils, C.E. Spier and M.P. Jones.  Effects of 100% oxygen and food  deprivation on cell division in lung alveoli of mice.  Exp Mol Pathol 26:350-358, 1977.

 

36. Evans, M.J. and L. Levy.  Failure of M. leprae to incorporate tritiated thymidine administered in  vivo.  Leprosy Rev 48:27-43, 1977.

 

37. Juhos, L.T., M.J. Evans, R. Mussenden-Harvey, N.J. Furiosi, C.E. Lapple and G. Freeman.   Limited exposure of rats to H2SO4 with and without O3. J Environ Sci Health, C13, 1978.

 

38. Evans, M.J., L.J. Cabral-Anderson and G. Freeman.  Role of the Clara cell in renewal of the  bronchiolar epithelium.  Lab Invest 38:648-655, 1978.

 

39. Evans, M.J., N. Dekker, L.J. Cabral-Anderson and G.Freeman.  Quantitation of damage to the  alveolar epithelium by means of Type II cell proliferation.  Am Rev Respir Dis 118:787-790, 1978.

 

40. Peters, J.H., M.J. Evans, R.A. Jensen and E.M. Acton.  Effects of 5-iminodaunorubicin on nucleoli  of rats.  Cancer Chemotherapy and Pharmacology 4:243-266, 1980.

 

41. Evans, M.J., L.J. Cabral-Anderson, N.P. Dekker and G. Freeman.  Effects of dietary antioxidants  on NO2 induced injury to Type I alveolar cells.  Chest 80:5-8, 1981.

 

42. Hackney, J.D., M.J. Evans, C.E. Spier, U.T. Anzar and K.W. Clark.  Effect of high concentrations  of oxygen on reparative regeneration of damaged alveolar epithelium in mice.  Exp Mol Pathol 34:338-344, 1981.

 

43. Evans, M.J. Oxidant gases. Environ Health Perspect 55:85-95, 1984.

 

44. Shami, S.G., T.M. Caton, W.C. Griffith and M.J. Evans.  An improved method for calculating labeling indices of lung epithelial and interstitial cells.  J Toxicol Environ Health 15:229-236, 1985.

 

45. Evans, M.J., N.P. Dekker, L.J. Cabral-Anderson and S.G. Shami.  Morphological basis of tolerance  to ozone.  Exp Mol Pathol 42:366-376, 1985.

 

46. Shami, S.G. and M.J. Evans.  The role of migratory inflammatory cells in proliferation of lung  epithelium and interstitium.  Chest 89:170-173, 1985.

 

47. Brooks, A.L., R.L. Guilmette, M.J. Evans and J.H. Diel.  The induction of chromosome aberrations in the liver of the Chinese hamster by injected thorotrast.  Strahlentherapie 80:197-201, 1985.

 

48. Evans, M.J., S.G. Shami and L.A. Martinez.  Enhanced proliferation of pulmonary alveolar  macrophages after carbon instillation in mice depleted of blood monocytes by strontium-89.  Lab Invest 54:154-159, 1986.

 

49. Evans, M.J. and S.G. Shami.  Role of nonciliated cells in the proliferative response of bronchial  epithelium in rats exposed to NO2.  Am J Pathol 123:126-133, 1986.

 

50. Shami, S.G., M.J. Evans and L.A. Martinez.  Type 2 cell proliferation related to migration of  inflammatory cells into the lung.  Exp Mol Pathol 44:344-352, 1986.

 

51. Bice, D.E., R.H. Gray, M.J. Evans and B.A. Muggenburg.  Identification of plasma cells on lung  alveoli and interstitial tissue after localized lung immunization.  J Leuk Biol 41:1-7, 1987.

 

52. Evans, M.J., M.P. Sherman, L.A. Campbell and S.G. Shami.  Proliferation of alveolar macrophages during postnatal development of rabbit lungs.  Am Rev Respir Dis 136:384-387, 1987.

 

53. Sherman, M.P., Evans, M.J. and L.A. Campbell.  Prevention of pulmonary alveolar macrophage  proliferation in newborn rabbits by hyperoxia.  J Pediatrics 112:782-786, 1988.

 

54. Evans, M.J. and C.G. Plopper.  The role of basal cells in adhesion of columnar epithelium to airway basement membrane.  Am Rev Respir Dis 138:481-483, 1988.